Oct 17, 2007  Painkiller: Overdose is the official follow-up released in 2004 shooting FPP, carried out by the Polish development studio People Can Fly. For the development of the sequel is, however, another company, namely Czech Mindware Studios. The Developer is known for productions such as Voodoo Nights (PC, X 360), and Cold War: Behind The Iron Curtain (PC, XBX). Oct 26, 2007  Painkiller: Overdose Review. This stand-alone Painkiller expansion is pure, stupid fun, despite slow loads and an utter lack of innovation.

Generic Name: Buprenorphine Transdermal Patch (byoo pre NOR feen)
Brand Name: Butrans

Medically reviewed by Drugs.com. Last updated on Jan 24, 2020.

Warning

• This medicine may cause very bad and sometimes deadly breathing problems. Call your doctor right away if you have slow, shallow, or trouble breathing.
• Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.
• This medicine has an opioid drug in it. Severe side effects have happened when opioid drugs were used with benzodiazepines or other drugs that may make you drowsy or slow your actions. This includes slow or troubled breathing and death. Benzodiazepines include drugs like alprazolam, diazepam, and lorazepam. Benzodiazepines may be used to treat many health problems like anxiety, trouble sleeping, or seizures. If you have questions, talk with your doctor.
• Many drugs interact with buprenorphine transdermal patch and can raise the chance of side effects like deadly breathing problems. Talk with your doctor and pharmacist to make sure it is safe to use buprenorphine transdermal patch with all of your drugs.
• Do not take with alcohol or products that have alcohol. Unsafe and sometimes deadly effects may happen.
• Get medical help right away if you feel very sleepy, very dizzy, or if you pass out. Caregivers or others need to get medical help right away if the patient does not respond, does not answer or react like normal, or will not wake up.
• Using buprenorphine transdermal patch for a long time during pregnancy may lead to withdrawal in the newborn baby. This can be life-threatening. Talk with the doctor.
• This medicine is a strong pain drug that can put you at risk for addiction, abuse, and misuse. Misuse or abuse of buprenorphine transdermal patch can lead to overdose and death. Talk with your doctor.
• You will be watched closely to make sure you do not misuse, abuse, or become addicted to buprenorphine transdermal patch.
• Do not take more than what your doctor told you to take. Taking more than you are told may raise your chance of very bad side effects.
• The chance of very bad and sometimes deadly breathing problems may be greater when you first start buprenorphine transdermal patch or anytime your dose is raised.
• Even one dose of buprenorphine transdermal patch may be deadly if it is taken by someone else or by accident, especially in children. If buprenorphine transdermal patch is taken by someone else or by accident, get medical help right away.
• Misuse or abuse of buprenorphine transdermal patch by placing it in the mouth or chewing, swallowing, injecting, or snorting it can lead to overdose and death.

Uses of Buprenorphine Transdermal Patch:

• It is used to ease very bad pain.
• It is only to be used when around-the-clock (continuous) care is needed for a long time. It is also only to be used when other pain drugs do not treat your pain well enough or you cannot take them.
• It may be given to you for other reasons. Talk with the doctor.

What do I need to tell my doctor BEFORE I take Buprenorphine Transdermal Patch?

• If you have an allergy to buprenorphine or any other part of buprenorphine transdermal patch.
• If you are allergic to buprenorphine transdermal patch; any part of buprenorphine transdermal patch; or any other drugs, foods, or substances. Tell your doctor about the allergy and what signs you had.
• If you have any of these health problems: Lung or breathing problems like asthma, trouble breathing, or sleep apnea; high levels of carbon dioxide in the blood; or stomach or bowel block or narrowing.
• If you have liver disease.
• If you or a family member have a long QT on ECG.
• If you are taking any of these drugs: Butorphanol, nalbuphine, or pentazocine.
• If you are using another drug that has the same drug in it.
• If you are taking any of these drugs: Certain drugs to treat a heartbeat that is not normal like amiodarone, disopyramide, dofetilide, procainamide, quinidine, or sotalol.
• If you are taking any drugs that can cause a certain type of heartbeat that is not normal (prolonged QT interval). There are many drugs that can do this. Ask your doctor or pharmacist if you are not sure.
• If you have taken certain drugs for depression or Parkinson's disease in the last 14 days. This includes isocarboxazid, phenelzine, tranylcypromine, selegiline, or rasagiline. Very high blood pressure may happen.
• If you are taking any of these drugs: Linezolid or methylene blue.
• If you are breast-feeding. Do not breast-feed while you take buprenorphine transdermal patch.

This is not a list of all drugs or health problems that interact with buprenorphine transdermal patch.

Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take buprenorphine transdermal patch with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.

What are some things I need to know or do while I take Buprenorphine Transdermal Patch?

• Tell all of your health care providers that you take buprenorphine transdermal patch. This includes your doctors, nurses, pharmacists, and dentists.
• Avoid driving and doing other tasks or actions that call for you to be alert until you see how buprenorphine transdermal patch affects you.
• To lower the chance of feeling dizzy or passing out, rise slowly if you have been sitting or lying down. Be careful going up and down stairs.
• Very bad and sometimes deadly liver problems have happened with buprenorphine transdermal patch. Call your doctor right away if you have signs of liver problems like dark urine, feeling tired, not hungry, upset stomach or stomach pain, light-colored stools, throwing up, or yellow skin or eyes.
• Long-term use of an opioid drug may lead to lower sex hormone levels. Call your doctor if you have a lowered interest in sex, fertility problems, no menstrual period (women), or change in sex ability (men).
• This medicine may raise the chance of seizures in some people, including people who have had seizures in the past. Talk to your doctor to see if you have a greater chance of seizures while taking buprenorphine transdermal patch.
• Taking an opioid drug like buprenorphine transdermal patch may lead to a rare but very bad adrenal gland problem. Call your doctor right away if you have very bad dizziness or passing out, very bad upset stomach or throwing up, or if you feel less hungry, very tired, or very weak.
• If you are 65 or older, use buprenorphine transdermal patch with care. You could have more side effects.
• This medicine may cause harm to the unborn baby if you take it while you are pregnant. If you are pregnant or you get pregnant while taking buprenorphine transdermal patch, call your doctor right away.
• Avoid use of heat sources (such as sunlamps, tanning beds, heating pads, electric blankets, heat lamps, saunas, hot tubs, heated waterbeds). Avoid long, hot baths or sunbathing. Your temperature may rise and cause too much drug to pass into your body.
• If the sticky side of the patch touches another person's skin, wash the area with water only, and get medical help right away.
• Long-term or regular use of opioid drugs like buprenorphine transdermal patch may lead to dependence. Lowering the dose or stopping buprenorphine transdermal patch all of a sudden may cause a greater risk of withdrawal or other severe problems. Talk to your doctor before you lower the dose or stop buprenorphine transdermal patch. You will need to follow your doctor’s instructions. Tell your doctor if you have more pain, mood changes, thoughts of suicide, or any other bad effects.
• If you have been taking buprenorphine transdermal patch for a long time or at high doses, it may not work as well and you may need higher doses to get the same effect. This is known as tolerance. Call your doctor if buprenorphine transdermal patch stops working well. Do not take more than ordered.
• This medicine is not approved for use in children. Talk with the doctor.

How is this medicine (Buprenorphine Transdermal Patch) best taken?

Use buprenorphine transdermal patch as ordered by your doctor. Read all information given to you. Follow all instructions closely.

• Do not take buprenorphine transdermal patch with other strong pain drugs or if you are using a pain patch without talking to your doctor first.
• If you drink grapefruit juice or eat grapefruit often, talk with your doctor.
• Have blood work checked as you have been told by the doctor. Talk with the doctor.
• This medicine may cause withdrawal symptoms if you are dependent or addicted to narcotics. Talk with your doctor.
• Use buprenorphine transdermal patch at the same time of day.
• Do not use if the pouch that holds buprenorphine transdermal patch is torn, open, or not sealed all the way.
• Do not use for fast pain relief or on an as needed basis.
• Do not use for pain relief after surgery if you have not been taking drugs like buprenorphine transdermal patch.
• Do not use patches that are cut or do not look right.
• Wash your hands before and after use.
• Take off old patch first.
• Put patch on clean, dry, healthy skin on the upper arm, upper back, upper chest, or side of the chest.
• If there is hair where you are putting the patch, clip the hair as close to the skin as you can. Do not shave the hair.
• Put the patch in a new area each time you change the patch.
• Do not put a new patch on the same skin area as an old patch for at least 21 days.
• If the patch falls off, put a new one on.
• If the patch loosens, put tape ONLY on the edges of the patch to hold it in place.
• If there are problems with the patch not sticking, cover the patch with dressings as you have been told.
• Do not put on more than 1 patch at the same time unless your doctor tells you to.

What do I do if I miss a dose?

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• Put on a missed patch as soon as you think about it after taking off the old one.
• Do not apply double dose or extra doses.

See also:

Buprenorphine dosage information (in more detail)

What are some side effects that I need to call my doctor about right away?

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:

• Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
• Sweating a lot.
• Fast, slow, or abnormal heartbeat.
• Feeling nervous and excitable.
• Fever, chills, or sore throat.
• Change in balance.
• Mood changes.
• Severe constipation or stomach pain. These may be signs of a severe bowel problem.
• Extra muscle action or slow movement.
• Swelling in the arms or legs.
• Change in eyesight.
• A burning, numbness, or tingling feeling that is not normal.
• Trouble speaking.
• Chest pain or pressure or passing out.
• Trouble passing urine.
• Hallucinations (seeing or hearing things that are not there).
• Muscle or joint pain.
• Memory problems or loss.
• Seizures.
• Shakiness.
• Slurred speech, stumbling, or feeling confused, very sleepy or dizzy, or drunk.
• Not able to focus.
• A severe and sometimes deadly problem called serotonin syndrome may happen if you take buprenorphine transdermal patch with certain other drugs. Call your doctor right away if you have agitation; change in balance; confusion; hallucinations; fever; fast or abnormal heartbeat; flushing; muscle twitching or stiffness; seizures; shivering or shaking; sweating a lot; severe diarrhea, upset stomach, or throwing up; or severe headache.

What are some other side effects of Buprenorphine Transdermal Patch?

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:

• Constipation.
• Upset stomach or throwing up.
• Stomach pain or diarrhea.
• Feeling dizzy, sleepy, tired, or weak.
• Headache.
• Trouble sleeping.
• Back pain.
• Dry mouth.
• Signs of a common cold.
• Skin irritation.

These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.

You may report side effects to the FDA at 1-800-332-1088. You may also report side effects at https://www.fda.gov/medwatch.

See also:

Buprenorphine side effects (in more detail)

If OVERDOSE is suspected:

If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

How do I store and/or throw out Buprenorphine Transdermal Patch?

• Store at room temperature in a dry place. Do not store in a bathroom.
• Store patches in pouch until ready for use.
• After you take off a skin patch, be sure to fold the sticky sides of the patch to each other. Throw away used patches where children and pets cannot get to them.
• Follow the info that comes with buprenorphine transdermal patch for throwing out patches that are used or not needed. Check with your pharmacist if you have questions about how to throw out buprenorphine transdermal patch.
• Throw away unused or expired drugs. Do not flush down a toilet or pour down a drain unless you are told to do so. Check with your pharmacist if you have questions about the best way to throw out drugs. There may be drug take-back programs in your area.

Consumer information use

• If your symptoms or health problems do not get better or if they become worse, call your doctor.
• Do not share your drugs with others and do not take anyone else's drugs.
• This medicine comes with an extra patient fact sheet called a Medication Guide. Read it with care. Read it again each time buprenorphine transdermal patch is refilled. If you have any questions about buprenorphine transdermal patch, please talk with the doctor, pharmacist, or other health care provider.
• If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Related questions

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